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Additionally, the indole core is substituted at R3 with a carbonyl group which can be also bonded to a napthalene moeity. Napthalene is usually a bicyclic framework of two fused benzene rings. This carbonyl bridge of JWH-018 classifies it as a ketone. JWH-018 is really an analog of THJ-018, in which the Main indazole structure is substituted using